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Imatinib mesylate

品牌：AG Scientific

货号：

规格：100 mg

货期：

应用：

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CAS:220127-57-1Formula:C29H31N7O.CH4SO3MW:589.71Appearance:Whitetooff-whiteSolidPurity:99%byHPLC

商品详情参考文献相关资料

An inhibitor of the bcr-abl tyrosine kinase. It acts by binding to the ATP of bcr-abl. Imatinib also stimulates the entry of the bcr-abl tyrosine kinase into the nucleus, where it cannot perform its anti-apoptopic functions. It inhibits EOL-1 cell viability (IC= 0.5 nM), phosphorylation of a fusion protein (IC= 30 nM), and viability of BaF3 cells expressing Rhe-PDGFR in the absence of IL-3 (IC= 0.17 nM).

Additional Information

Synonyms	CGP-57148B, STI-571
Product #	I-2359
CAS #	220127-57-1
Chemical Name	N-(4-METHYL-3-((4-(PYRIDIN-3-YL)PYRIMIDIN-2-YL)AMINO)PHENYL)-4-((4-METHYLPIPERAZIN-1-YL)METHYL)BENZAMIDE METHANESULFONATE
Formula	C₂₉H₃₁N₇O.CH₄SO₃
MW	589.71
Appearance	White to off-white Solid
Purity	99% by HPLC
Solubility	DMSO (100 mg/ml)
Melting Point	214-224 °C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	Imatinib mesylate is a tyrosine kinase inhibitor with antineoplastic activity

Additional Information

MDL Number	MFCD04307699
ChemACX	X1493265-9
InChI	InChI=1S/C29H31N7O.CH4O3S/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36;1-5(2,3)4/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34);1H3,(H,2,3,4)
SMILES	Cc1ccc(cc1Nc2nccc(n2)c3cccnc3)NC(=O)c4ccc(cc4)CN5CCN(CC5)C.CS(=O)(=O)O

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