Geldanamycin | CAS [30562-34-6] | binds HSP90 | anti-tumor activity | A.G.Scien |产品详情|进口橙子视频旧款采购网

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Geldanamycin | CAS [30562-34-6] | binds HSP90 | anti-tumor activity | A.G.Scien

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Geldanamycin | CAS [30562-34-6] | binds HSP90 | anti-tumor activity | A.G.Scien

品牌：AG Scientific

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规格：500 ug

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CAS:30562-34-6Formula:C29H40N2O9MW:560.6Appearance:YellowSolidPurity:98.4%

商品详情参考文献相关资料

Geldanamycin is a benzoquinone ansamycin antibiotic which binds to Hsp90 (Heat Shock Protein 90) and alters it function. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, and oncogenesis.Cdc28 provides a molecular link between Hsp90, morphogenesis, and cell cycle progression inCandida albicans.Epidermal Growth Factor Receptors with Tyrosine Kinase Domain Mutations Exhibit Reduced Cbl Association, Poor Ubiquitylation, and Down-regulation but Are Efficiently Internalized.Inhibition of HSP90 in Trypanosoma cruzi Induces a Stress Response but No Stage Differentiation, Role of the Heat Shock Protein 90 in Immune Response Stimulation by Bacterial DNA and Synthetic Oligonucleotides.

Additional Information

Synonyms	GA
Product #	G-1047
CAS #	30562-34-6
Chemical Name	[(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-HYDROXY-5,11,21-TRIMETHOXY-3,7,9,15-TETRAMETHYL-16,20,22-TRIOXO-17-AZABICYCLO[16.3.1]DOCOSA-1(21),8,12,14,18-PENTAEN-10-YL] CARBAMATE
Formula	C₂₉H₄₀N₂O₉
MW	560.6
Appearance	Yellow Solid
Purity	98.4%
Solubility	DMSO: Clear yellow solution at 10 mg/ml, CH₂Cl₂: Clear yellow solution at 5 mg/ml
Melting Point	260°C
Storage Temp	-20°C. PROTECT FROM LIGHT!
Therapeutic Area	Oncological Disorders
Use	Geldanamycin Analogue in Treating Patients With Colon Cancer

Additional Information

MDL Number	MFCD00274570
ChemACX	X1035747-8
InChI	InChI=1S/C29H40N2O9/c1-15-11-19-25(34)20(14-21(32)27(19)39-7)31-28(35)16(2)9-8-10-22(37-5)26(40-29(30)36)18(4)13-17(3)24(33)23(12-15)38-6/h8-10,13-15,17,22-24,26,33H,11-12H2,1-7H3,(H2,30,36)(H,31,35)/b10-8-,16-9+,18-13+/t15-,17+,22+,23+,24-,26+/m1/s1
SMILES	C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)/C)OC)OC(=O)N)C)C)O)OC

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