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CAS 129-56-6 SP-600125 is a potent, cell permeable, selective, and reversible i |产品详情|进口橙子视频旧款采购网




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    CAS 129-56-6 SP-600125 is a potent, cell permeable, selective, and reversible i
    品牌:AG Scientific
    货号:
    规格:5 mg
    货期:

    CAS:129-56-6Formula:C14H8N2OMW:220.2Appearance:YellowsolidPurity:>98%

    商品详情 参考文献 相关资料

    SP600125, SP-600125 is a potent, cell permeable, selective, and reversible inhibitor of c-Jun N-terminal kinase (JNK) (IC50 = 40nM for JNK-1 and JNK-2 and 90nM for JNK-3).
    SP600125, SP-600125 exhibits over 300-fold greater selectivity for JNK as compared to ERK1 and p38.

    * Listed below are a few published articles demonstrating the use of our SP600125. Inquire for a full list of references.

    • ERα mediates alcohol-induced deregulation of Pol III genes in breast cancer cells. Qingsong Zhang, Jian Jin, Qian Zhong, et al. Carcinogenesis. Jan 2013. 34: 28 - 37.
    • FcαRI-Mediated Inhibition of IL-12 Production and Priming by IFN- of Human Monocytes and Dendritic Cells. Marylène Lecocq, Bruno Detry, et al. J. Immunol. Mar 2013. 190: 2362 - 2371.
    • MyD88-deficient Hydra reveal an ancient function of TLR signaling in sensing bacterial colonizers. Sören Franzenburg, et al. PNAS. Nov 2012. 109: 19374 - 19379.
    • Candida albicans and Candida parapsilosis Induce Different T-Cell Responses in Human Peripheral Blood Mononuclear Cells, Adél Tóth et al. J Infect Dis. 2013. 208: 690-698. first published online May 9, 2013.
    • Airway smooth muscle CXCR3 ligand production: regulation by JAK-STAT1 and intracellular Ca2+
    • Trained Immunity or Tolerance: Opposing Functional Programs Induced in Human Monocytes after Engagement of Various Pattern Recognition Receptors.  Ifrim, D. C. et al. Clin. Vaccine Immunol. Apr 2014. 21: 534-545.
    • Early growth response protein-1 mediates lipotoxicity-associated placental inflammation: role in maternal obesity.  Saben, J. et al. Am J Physiol Endocrinol Metab. Jul 2013. 305: E1-E14. 
    • THERAPEUTICS, TARGETS AND CHEMICAL BIOLOGY: Induction of DNA Damage-Inducible Gene GADD45β Contributes to Sorafenib-Induced Apoptosis in Heptocellular Carcinoma Cells. Ou, D.L. et al. Cancer Res. Nov 2010. 70: 9309-9318.
    • IMMUNOLOGY: MyD88-deficient Hydra reveal an ancient function of TLR signaling in sensing bacterial colonizers. Frazenburg, S. et al. PNAS. Nov 2012. 109: 19374-19379.
    • IMMUNOLOGY: Actin-binding protein 1 links B-cell antigen receptors to negative signaling pathways. Seeley-Fallen, M. K. et al. PNAS. Jul 2014. 111:9881-9886.
    • Asthmatic airway smooth muscle CXCL10 production: mitogen-activated protein kinase JNK involvement. Alrashdan, Y. A. et al. Am J Physiol Lung Cell Mol Physiol. May 2012. 302: L1118-L1127.
    • Th1 cytokine-induced syndecan-4 shedding by airway smooth muscle cells is dependent on mitogen-activated protein kinases. Tan, X. et al. Am J Physiol Lung Cell Mol Physiol. Apr 2012. 302: L700-L710.
    • TGF-ß enhances deposition of perlecan from COPD airway smooth muscle. Ichimaru, Y. et al. Am J Physiol Lung Cell Mol Physiol. Feb 2012. 302: L325-L333.
    • DNA AND CHROMOSOMES: Interleukin-1ß Induces Increased Transcriptional Activation of the Transforming Growth Factor-ß-activating Integrin Subunit ß8 through Altering Chromatin Architecture. Markovics, J. A. et al. J. Biol. Chem. Oct 2011. 286: 36864-36874. 

    Additional Information

    Product #S-2022
    CAS #129-56-6
    Chemical NameAnthra (1,9-cd)pyrazol-6(2H)-one;1,9- Pyrazoloanthrone
    FormulaC14H8N2O
    MW220.2
    AppearanceYellow solid
    Purity>98%
    SolubilitySoluble in DMSO(22 mg/ml) or ethanol (2mg/ml)
    Storage Temp-20°C, Store in Tightly Sealed Vial. Protect from Light.

    Additional Information

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