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Cell-permeable. A potent inhibitior of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (Kd = 1.2 nM). Inhibits smoothened agonist effects with an ICof 20 nM in Shh-LIGHT2 cells. SANT-1 inhibits both wild type and oncogenic Smo with equal potency.

Additional Information

Synonyms	N-[3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine
Product #	S-2162
CAS #	304909-07-7
Chemical Name	N-[3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine
Formula	C23H27N5
MW	373.49
Appearance	Pale yellow Solid
Purity	98% by HPLC
Solubility	DMSO (~50 mM) or EtOH (~25 mM)
Storage Temp	Store at -20°C. Protect from air and light.
Therapeutic Area	Oncological Disorders
Use	A Smo inhibitor and Sonic Hedgehog signaling pathway antagonist use in cancer

Additional Information

MDL Number	MFCD01827306
ChemACX	X1438040-4
InChI	InChI=1S/C23H27N5/c1-19-23(20(2)28(25-19)22-11-7-4-8-12-22)17-24-27-15-13-26(14-16-27)18-21-9-5-3-6-10-21/h3-12,17H,13-16,18H2,1-2H3/b24-17+
SMILES	Cc1c(c(n(n1)c2ccccc2)C)/C=N/N3CCN(CC3)Cc4ccccc4