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A small-molecule chemical inhibitor of Sonic hedgehog (Shh) signaling, that blocks hedgehog signaling through specific binding and blockade of Shh signaling factor. It is the first characterized hedgehog inhibitor whose molecular mechanism of action is through blockade of Shh protein and not a factor of the hedgehog signaling cascades.Robotnikinin binds to the Shh-N terminal protein in a concentration-dependent fashion with a K of 9M.Robotnikinin is an embryogenesis inhibitor such as in the growth in digits on limbs and organization of the brain. Morphogenetic activity, Shh signaling is centrally responsible in the ventral portion of the neural tube and the induction of floor plate cells and motor neurons.Robotbikinin, an inhibitor of the Hedgehog signaling pathway, has been found and dubbed 'Robotnikinin'.

Additional Information

Synonyms	N-[(Chlorophenyl)methyl]-2-[2R,6S,8E)-5, 12-Dioxo-2-phenyl-1-oxa-4-azacyclododec-8-en-6-yl]acetamide
Product #	R-2028
Chemical Name	N-[(Chlorophenyl)methyl]-2-[2R,6S,8E)-5, 12-Dioxo-2-phenyl-1-oxa-4-azacyclododec-8-en-6-yl]acetamide
Formula	C25H27ClN2O4
MW	454.95
Appearance	White Solid
Purity	97%
Solubility	Soluble in DMSO
Storage Temp	-20°C

Additional Information

ChemACX	X5334459-9
InChI	InChI=1S/C25H27ClN2O4/c26-21-13-11-18(12-14-21)16-27-23(29)15-20-9-5-2-6-10-24(30)32-22(17-28-25(20)31)19-7-3-1-4-8-19/h1-5,7-8,11-14,20,22H,6,9-10,15-17H2,(H,27,29)(H,28,31)/b5-2-/t20-,22-/m0/s1
SMILES	C1CC(=O)O[C@@H](CNC(=O)[C@@H](C/C=C1)CC(=O)NCC2=CC=C(C=C2)Cl)C3=CC=CC=C3