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A constituent of the pepper Piper longum L. that selectively kills cancer cells but not normal cells. Piperlongumine increases the level of reactive oxygen species (ROS) and apoptotic cell death in both cancer cells and normal cells engineered to have a cancer genotype, irrespective of p53 status, but it has little effect on either rapidly or slowly dividing primary normal cells. Also potently inhibits the growth of spontaneously formed malignant breast tumors and their associated metastases in mice.

Additional Information

Synonyms	(E)-1-(3-(3,4,5-Trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one; 1-[(2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-5,6-dihydropyridin-2(1H)-one; Piplartine
Product #	P-2399
CAS #	20069-09-4
Chemical Name	(E)-1-(3-(3,4,5-Trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one; 1-[(2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-5,6-dihydropyridin-2(1H)-one; Piplartine
Formula	C17H19NO6
MW	317.34
Appearance	White to off-white Solid
Purity	97%
Solubility	DMSO (~ 25 mg/ml)
Melting Point	123-124 °C
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	A selective anticancer GSTP1 inhibitor

Additional Information

MDL Number	MFCD00075706
ChemACX	X1095211-1
InChI	InChI=1S/C17H19NO5/c1-21-13-10-12(11-14(22-2)17(13)23-3)7-8-16(20)18-9-5-4-6-15(18)19/h4,6-8,10-11H,5,9H2,1-3H3/b8-7+
SMILES	COc1cc(cc(c1OC)OC)/C=C/C(=O)N2CCC=CC2=O