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GDC-0941

品牌：AG Scientific

货号：

规格：1 mg

货期：

应用：

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CAS:957054-30-7Formula:C23H27N7O3S2MW:513.64Appearance:Off-WhiteSolidPurity:99%byHPLC

商品详情参考文献相关资料

GDC-0941 is a potent inhibitor of p110 and p110 (IC= 3 nM). It selectively binds to PI3K isoforms in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway.

Additional Information

Synonyms	2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-thieno[3,2- d]pyrimidine
Product #	G-2335
CAS #	957054-30-7
Chemical Name	2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-thieno[3,2- d]pyrimidine
Formula	C₂₃H₂₇N₇O₃S₂
MW	513.64
Appearance	Off-White Solid
Purity	99% by HPLC
Solubility	DMSO
Storage Temp	-20°C
Therapeutic Area	Oncological Disorders
Use	A potent inhibitor the PI 3-kinase family in tumor cell proliferation, induces apoptosis

Additional Information

MDL Number	MFCD11616196
ChemACX	X1759141-2
InChI	InChI=1S/C23H27N7O3S2/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4,13-14H,5-12,15H2,1H3,(H,24,27)
SMILES	CS(=O)(=O)N1CCN(CC1)Cc2cc3c(s2)c(nc(n3)c4cccc5c4cn[nH]5)N6CCOCC6

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