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R-(R)-Roscovitine, selective CDK Inhibitor

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R-(R)-Roscovitine, selective CDK Inhibitor

品牌：AG Scientific

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规格：5 mg

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CAS:186692-46-6Formula:C19H26N6OMW:354.5Appearance:WhiteSolid,powder.Purity:>99%

商品详情参考文献相关资料

Potent and selective inhibitor of cyclin-dependent kinases (cdks). Selective for CDK1, CDK2, and CDK5.A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma.Glycogen Synthase Kinase-3 Plays a Central Role in Mediating Glucocorticoid-Induced Apoptosis.Dying and Necrotic Neutrophils Are Anti-Inflammatory Secondary to the Release of -Defensins.Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages.Pkd1 and Nek8 mutations affect cell-cell adhesion and cilia in cysts formed in kidney organ cultures.

Additional Information

Synonyms	2-(R)-1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine,Roscovitine
Product #	R-1016
CAS #	186692-46-6
Chemical Name	2-(R)-1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine
Formula	C₁₉H₂₆N₆O
MW	354.5
Appearance	White Solid, powder.
Purity	>99%
Solubility	Soluble in chloroform (50mg/ml), ethanol or warm DMSO @ (10mg/ml), or methanol; moderately soluble in water.
Storage Temp	Keep cool and dry at -20°C. Protect from light!
Therapeutic Area	Oncological Disorders
Use	A potent and selective inhibitor of cyclin-dependent kinases. Selective for CDK1, CDK2, and CDK5

Additional Information

MDL Number	MFCD02266401
ChemACX	X1192610-4
InChI	InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1
SMILES	CC[C@H](CO)Nc1nc(c2c(n1)n(cn2)C(C)C)NCc3ccccc3

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