Pepstatin A CAS 26305-03-3 inhibits lysosomal proteases directly |产品详情|进口橙子视频旧款采购网

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Pepstatin A CAS 26305-03-3 inhibits lysosomal proteases directly

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Pepstatin A CAS 26305-03-3 inhibits lysosomal proteases directly

品牌：AG Scientific

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规格：5 mg

货期：

应用：

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CAS:26305-03-3Formula:C34H63N5O9MW:685.91Appearance:WhitePowderPurity:≤98%

商品详情参考文献相关资料

Pepstatin A is a competitive, reversible aspartic protease inhibitor and inhibits proteases such as pepsin, chymosin, renin, HIV proteases, and cathepsins D and E. It is highly selective and is often used in a mixture with other enzyme inhibitors. In vitro studies have shown pepstatin A is the only aspartic acid inhibitor that exhibits inhibitory effects on HIV proteases. Pepstatin A may also suppress differentiation of osteoclasts by inhibiting phosphorylation of MAP kinase and inhibiting NFATc1 expression. Pepstatin A has an application in cold inducible RNA-binding protein (CIRP) via CRISPR-Cas9 system. Pepstatin A inhibits lysosomal proteases directly.

Additional Information

Synonyms	Isovaleryl-L-Val-L-Val-AHMHA-L-Ala-AHMHA (AHMHA=(3S, 4S)-4-Amino-3-hydroxy-6-methyl-heptanoic acid)
Product #	P-1519
CAS #	26305-03-3
Chemical Name	Isovaleryl-L-Val-L-Val-AHMHA-L-Ala-AHMHA (AHMHA=(3S, 4S)-4-Amino-3-hydroxy-6-methyl-heptanoic acid)
Formula	C₃₄H₆₃N₅O₉
MW	685.91
Appearance	White Powder
Purity	≤98%
Solubility	DMSO (5 mg/ml) or Methanol (1 mg/ml)
Storage Temp	Store Desiccated at -20°C. Protect from light.
Use	Pepstatin A is a potent reversible inhibitor of aspartic proteases.

Additional Information

MDL Number	MFCD00060740
ChemACX	X1036275-1
InChI	InChI=1S/C34H63N5O9/c1-17(2)12-23(37-33(47)31(21(9)10)39-34(48)30(20(7)8)38-27(42)14-19(5)6)25(40)15-28(43)35-22(11)32(46)36-24(13-18(3)4)26(41)16-29(44)45/h17-26,30-31,40-41H,12-16H2,1-11H3,(H,35,43)(H,36,46)(H,37,47)(H,38,42)(H,39,48)(H,44,45)/t22-,23-,24-,25-,26-,30-,31-/m0/s1
SMILES	C[C@@H](C(=O)N[C@@H](CC(C)C)[C@H](CC(=O)O)O)NC(=O)C[C@@H]([C@H](CC(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)CC(C)C)O
Peptide Sequence	ISOVALERYL-VAL-VAL-STA-ALA-STA-OH