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NHI-2 | LDHA inhibitor

品牌：AG Scientific

货号：

规格：10 mg

货期：

应用：

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CAS:1269802-97-2Formula:C17H12F3NO3MW:335.28Appearance:Off-whitesolidPurity:98%byHPLCNMR(Confirms)

商品详情参考文献相关资料

NHI-2 (1269802-97-2) is a selective inhibitor of Lactate Dehydrogenase A (LDHA) - IC₅₀ in vitro = 14.7 μM (NADH), 10.5 μM (Pyruvate). NHI-2 has also shown cellular growth inhibitory effects against pancreatic cancer cells (PANC-1 cells IC₅₀ = 22.2 μM normoxic and 4.0 μM hypoxic; LPC006 cells IC₅₀ = 17.8 μM normoxic and 1.1 μM hypoxic) with increased efficacy in a cancer cells hypoxic environment. LDHA is a key enzyme involved in the Warburg effect and a cancer cells ability to survive in a hypoxic environment.

Additional Information

Product #	N-2751
CAS #	1269802-97-2
Formula	C₁₇H₁₂F₃N_O₃
MW	335.28
Appearance	Off-white solid
Purity	98% by HPLC NMR (Confirms)
Solubility	Soluble in DMSO (up to 25 mg/ml).
Storage Temp	-20°