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Biological Activity:

UNC2327 is a potent and selective allosteric protein arginine methyltransferase 3 (PRMT3) inhibitor with IC50 ~ 230 nM. It occupies a novel allosteric and is noncompetitive with both the peptide substrate and cofactor.

How to Use:

In vitro: UNC2327 was used at 5-10 µM final concentration in various in vitro assays.
In vivo: n/a

Reference:

• 1. Liu F, et al. Exploiting an allosteric of PRMT3 yields potent and selective inhibitors. (2013) J Med Chem. 56(5):2110-24.