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Biological Activity:

MSAB is a potent and selective Wnt/β-catenin inhibitor identified using cell-based chemical screening. It binds to β-catenin, promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB shows potent anti-tumor effects selectively on Wnt-dependent cancer cells in vitro and in mouse cancer models.

How to Use:

In vitro: MSAB was suggested to be used at 5-10 µM final concentration in vitro.
In vivo: MSAB was used to dose mice at 10-20 mg/kg by intraperitoneal injection once per day in xenograft model of HCT116, HCT115 and H23 cell lines, and MMTV-Wnt1 transgenic mice.

Reference:

• 1. Hwang SY, et al. Direct Targeting of β-Catenin by a Small Molecule Stimulates Proteasomal Degradation and Suppresses Oncogenic Wnt/β-Catenin Signaling. (2016) Cell Rep. 16(1):28-36.