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AS8351,KDM5BInhibitor M60330-2s|产品详情|进口橙子视频旧款采购网




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    订购信息
    上海橙子视频app安卓下载生物科技公司
    Tel:400-968-7988    021-33779008
    AS8351,KDM5BInhibitor
    品牌:Xcessbio
    货号:M60330-2s
    规格:2 mg solid
    货期:

    AS8351,KDM5BInhibitor

    商品详情 参考文献 相关资料
    Product Information
    Molecular Weight: 291.31
    Formula: C17H13N3O2
    Purity: ≥98%
    CAS#: 796-42-9
    Solubility: DMSO up to 100 mM
    Chemical Name: 2-Hydroxy-1-naphthaldehyde isonicotinoylhydrazone
    Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

    Biological Activity:

    AS8351 is a potent iron chelator that has been found to inhibit of histone demethylase KDM5B (JARID1B) by competing with a-ketoglutarate. KDM5B a histone H3K4 demethylase involved in regulation of cell proliferation and stem cell self-renewal and differentiation. It can induce reprogramming of human fetal lung fibroblasts into functional cardiomyocytes, in combination with CHIR99021, A83-01, BIX01294, SC1, Y-27632, OAC2, SU16f and JNJ10198409.

    How to Use:

    In vitro: AS8351 was used at 1-10 µM in vitro and cellular assays.
    In vivo: n/a

    Reference:

    • 1. Cao N, et al. Conversion of human fibroblasts into functional cardiomyocytes by small molecules. (2016) Science. 352(6290):1216-20.


     
         


    Products are for research use only. Not for human use. 

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