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 OICR9429,WDR5Antagonist M60255-2s|产品详情|进口橙子视频旧款采购网




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    订购信息
    上海橙子视频app安卓下载生物科技公司
    Tel:400-968-7988    021-33779008
    OICR9429,WDR5Antagonist
    品牌：Xcessbio
    货号：M60255-2s
    规格：2 mg solid
    货期：

    OICR9429,WDR5Antagonist
    商品详情 参考文献 相关资料
    Product Information
    Molecular Weight: 555.59
    Formula: C29H32F3N5O3
    Purity: ≥98%
    CAS#: n/a
    Solubility: DMSO up to 50 mM
    Chemical Name: N-(4-(4-methylpiperazin-1-yl)-3'-(morpholinomethyl)-[1,1'-biphenyl]-3-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide
    Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

    Biological Activity:

    OICR9429 is a potent and selective WD repeat-containing protein 5 (WDR5) antagonist (Kd ~24-52 nM). It has >100-fold selectivity over other methyltransferases tested. It disrupts WDR5 interaction with peptide regions of MLL and Histone 3. OICR-9429 also disrupts the interaction of WDR5 with MLL1 and RbBP5 in cells with IC50 values below 1 µM.

    How to Use:

    In vitro: OICR9429 was used at 5-10 µM final concentration in various in vitro assays.
    In vivo:     n/a

    Reference:

    • 1. http://www.thesgc.org/chemical-probes/OICR-9429. 


     
         


    Products are for research use only. Not for human use.

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