Y-320---IL-17Immunomodulator M60200-2s|产品详情|进口橙子视频旧款采购网

您好，欢迎来到橙子视频app安卓下载生物网站！请登录注册

我的订单 | 联系橙子视频app安卓下载 | 在线客服QQ：3012681483 | 客服电话：400-968-7988 | 工作时间：08:30-17:30

主营产品： ELISA91橙子视频、抗体、补体血清、兔补体、干扰素、小鼠测温仪、进口橙子视频旧款、Quidel代理、Swant代理、PBL Assay Science代理

网站首页产品中心代理品牌新闻资讯资源中心关于橙子视频app安卓下载

所在位置：首页 > 产品中心 > Xcessbio > Xcessbio产品

订购信息

上海橙子视频app安卓下载生物科技公司

Tel:400-968-7988 021-33779008

Y-320---IL-17Immunomodulator

品牌：Xcessbio

货号：M60200-2s

规格：2mg solid

货期：

应用：

咨询客服

立即购买加入购物车

Y-320---IL-17Immunomodulator

商品详情参考文献相关资料

Product Information

Molecular Weight:	505.01
Formula:	C₂₇H₂₉ClN₆O₂
Purity:	≥98%
CAS#:	288250-47-5
Solubility:	DMSO up to 20 mM
Chemical Name:	1-(4-chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-carboxamide
Storage:	Powder: 4^oC 1 year. DMSO: 4^oC 3 month; -20^oC 1 year.

Biological Activity:

Y-320 is an orally active potent immunomodulator. It inhibits IL-15-induced IL-17 production by CD4 T cells with an IC₅₀ of 20 nM. Therapeutic treatment with Y-320 (0.3 to 3 mg/kg orally) significantly inhibited the progression of arthritis and joint destruction in type II collagen-induced arthritis (CIA) in DBA/1J mice. Y-320 inhibited the elevation of IL-17 mRNA expression in the joint of CIA mice. Concomitant treatment with Y-320 and anti-mouse TNF-alpha antibody showed a synergistic effect in mouse CIA. Moreover, therapeutic treatment with Y-320 (0.3 and 1 mg/kg orally) ameliorated CIA in cynomolgus monkeys.

How to Use:

In vitro: Y-320 was used at 0.1-1 µM final concentration in various in vitro assays.
In vivo: Y-320 was administered orally at 0.3-3 mg/kg once day in mouse models.

Reference:

1. Ushio H, et al. A New Phenylpyrazoleanilide, Y-320, Inhibits Interleukin 17 Production and Ameliorates Collagen-Induced Arthritis in Mice and Cynomolgus Monkeys. (2013) Pharmaceuticals (Basel) 7(1), 1-17.

Products are for research use only. Not for human use.

热销产品