Warning: mkdir(): No space left on device in /www/wwwroot/zhenghe1718.com/func.php on line 127

Warning: file_put_contents(./cachefile_yuan/pkscc.com/cache/b2/c6bd5/5340d.html): failed to open stream: No such file or directory in /www/wwwroot/zhenghe1718.com/func.php on line 115
 Y-320---IL-17Immunomodulator M60200-2s|产品详情|进口橙子视频旧款采购网




  • 橙子视频app安卓下载,91橙子视频,橙子视频旧款,橙子视频在线官网

    订购信息
    上海橙子视频app安卓下载生物科技公司
    Tel:400-968-7988    021-33779008
    Y-320---IL-17Immunomodulator
    品牌:Xcessbio
    货号:M60200-2s
    规格:2mg solid
    货期:

    Y-320---IL-17Immunomodulator

    商品详情 参考文献 相关资料
    Product Information
    Molecular Weight: 505.01
    Formula: C27H29ClN6O2
    Purity: ≥98%
    CAS#: 288250-47-5
    Solubility: DMSO up to 20 mM
    Chemical Name: 1-(4-chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-carboxamide
    Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

    Biological Activity:

    Y-320 is an orally active potent immunomodulator. It inhibits IL-15-induced IL-17 production by CD4 T cells with an IC50 of 20 nM. Therapeutic treatment with Y-320 (0.3 to 3 mg/kg orally) significantly inhibited the progression of arthritis and joint destruction in type II collagen-induced arthritis (CIA) in DBA/1J mice. Y-320 inhibited the elevation of IL-17 mRNA expression in the joint of CIA mice. Concomitant treatment with Y-320 and anti-mouse TNF-alpha antibody showed a synergistic effect in mouse CIA. Moreover, therapeutic treatment with Y-320 (0.3 and 1 mg/kg orally) ameliorated CIA in cynomolgus monkeys.

     

    How to Use:

    • In vitro:  Y-320 was used at 0.1-1 µM final concentration in various in vitro assays.
    • In vivo:  Y-320 was administered orally at 0.3-3 mg/kg once day in mouse models.

     

    Reference:

    1. 1. Ushio H, et al. A New Phenylpyrazoleanilide, Y-320, Inhibits Interleukin 17 Production and Ameliorates Collagen-Induced Arthritis in Mice and Cynomolgus Monkeys. (2013)  Pharmaceuticals (Basel) 7(1), 1-17.

     

    •      

     

    Products are for research use only. Not for human use.

    • 关于橙子视频app安卓下载
    • 购物流程
    • 支付方式
    • 配送方式
    Copyright@ 2003-2026  进口橙子视频旧款采购网版权所有     

    BIOLEAF热搜   BIOLEAF91橙子视频   BIOLEAF ELISA   BIOLEAF橙子视频旧款   BIOLEAF品牌   BIOLEAF抗体   BIOLEAF耗材   BIOLEAF小仪器

    sitemap   细胞库查询   危险品图标

    本公司网站所展示销售的产品仅供科研!

             沪ICP备08023583号-6     
    产品咨询
    QQ扫码沟通
    在线客服
    服务电话
    400-968-7988
    扫码关注
    微信公众号二维码

    沪公网安备 31011202007338号

    网站地图