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Optovin,TRPA1Activator M60103-2s|产品详情|进口橙子视频旧款采购网




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    订购信息
    上海橙子视频app安卓下载生物科技公司
    Tel:400-968-7988    021-33779008
    Optovin,TRPA1Activator
    品牌:Xcessbio
    货号:M60103-2s
    规格:2 mg solid
    货期:

    Optovin,TRPA1Activator

    商品详情 参考文献 相关资料
    Product Information
    Molecular Weight: 315.41
    Formula: C15H13N3OS2
    Purity: ≥ 98%
    CAS#: 348575-88-2
    Solubility: DMSO up to 50 mM
    Chemical Name: (E)-5-((2,5-dimethyl-1-(pyridin-3-yl)-1H-pyrrol-3-yl)methylene)-2-thioxothiazolidin-4-one
    Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

    Biological Activity:

    Optovin is a potent and selective small molecule activator of human TRPA1, identified through a high throughput zebrafish behavior screening. It activates human TRPA1 via photochemical reactions with redox-sensitive cysteine residues (EC50 ~2 µM), and enables repeated photoactivation of motor behaviors in wild-type zebrafish and mice. Optovin’s behavioral effects are not visually mediated. Rather, photodetection is performed by sensory neurons expressing the cation channel TRPA1. In animals with severed spinal cords, optovin treatment enables control of motor activity in the paralyzed extremities by localized illumination. These studies identify a light-based strategy for controlling endogenous TRPA1 receptors in vivo, with potential clinical and research applications in nontransgenic animals, including humans.


    How to Use:

    • In vitro: Optovin was used at 10 µM final concentration in vitro and in cellular assays.
    • In vivo: Optovin was suggested to be delivered on the ear for 20 μL of optovin solution (15 mM in DMSO).

    Reference:


    1. 1. Kokel D, et al. Photochemical activation of TRPA1 channels in neurons and animals. (2013) Nat Chem Biol. 9(4):257-63.





    Products are for research use only. Not for human use.

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