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Biological Activity:

FASCIN-G2 is a potent, selective and bioavailable small molecule that inhibits the actin-bundling activity of fascin with Kd ~5-20 µM. It specifically blocks filopodial formation, tumour cell migration and invasion in vitro. , FASCIN-G2 showed very good in vivo efficacy in 4T1 mammary tumour metastasis model and in MDA-MB-231 human breast tumour metastasis model.

How to Use:

In vitro: FASCIN-G2 was usually used at 10-50 µM final concentration in vitro.
In vivo: FASCIN-G2 was dosed to mice by intraperitoneal injection at 100 mg/Kg once per day in 4T1 mammary tumour metastasis model or in MDA-MB-231 human breast tumour metastasis model.

Reference:

• 1. Huang FK, et al. Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization. (2015) Nat Commun. 6:7465.