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 TZ9,Rad6UbiquitinInhibitor M60286-2s|产品详情|进口橙子视频旧款采购网




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    上海橙子视频app安卓下载生物科技公司
    Tel:400-968-7988    021-33779008
    TZ9,Rad6UbiquitinInhibitor
    品牌:Xcessbio
    货号:M60286-2s
    规格:2 mg solid
    货期:

    TZ9,Rad6UbiquitinInhibitor

    商品详情 参考文献 相关资料
    Product Information
    Molecular Weight: 366.34
    Formula: C17H14N6O4
    Purity: ≥98%
    CAS#: 1002789-86-7
    Solubility: DMSO up to 50 mM
    Chemical Name: (4-amino-6-(phenylamino)-1,3,5-triazin-2-yl)methyl 4-nitrobenzoate
    Storage: Powder: 4oC 1 year. DMSO: 4oC 3 month; -20oC 1 year.

    Biological Activity:

    TZ9 is a selective and cell permeable inhibitor of human E2 ubiquitin-conjugating enzyme Rad6B. It binds to the Rad6B catalytic site, inhibits Rad6B-induced histone H2A ubiquitination, downregulates intracellular β-catenin. It can induce G2/M arrest and apoptosis, and inhibit proliferation and migration of metastatic human breast cancer cells (IC50 ~6 µM).

    How to Use:

    In vitro: TZ9 was used at 10-50 µM final concentration in vitro and in cellular assays.
    In vivo: n/a


    Reference:

    • 1. Sanders MA, et al. Novel inhibitors of Rad6 ubiquitin conjugating enzyme: design, synthesis, identification, and functional characterization. (2013) Mol Cancer Ther. 12(4):373-83.


          
          


    Products are for research use only. Not for human use. 

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