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Biological Activity:

SW033291 is a highly potent and selective inhibitor of 15-PGDH enzyme with IC50 1.5 nM, can increase prostaglandin PGE2 levels in bone marrow and other tissues. It inhibits 15-PGDH with noncompetitive pattern. Treatment of A549 cells with SW033291 increased PGE2 levels by 3.5-fold at 500 nM, with EC50 value of ~75 nM. SW033291 accelerates hematopoietic recovery in mice receiving a bone marrow transplant. It also promotes tissue regeneration in mouse models of colon and liver injury. Tissues from 15-PGDH knockout mice demonstrate similar increased regenerative capacity. SW033291is a good compound to validate 15-PGDH inhibition could be a new therapeutic strategy for tissue regeneration in diverse clinical contexts.

How to Use:

In vitro: SW033291 was used at 1 µM in vitro and cellular assays.
In vivo: SW033291 was dosed to mice by intraperitoneal injection at 5-10 mg/Kg once or twice per day.

Reference:

• 1. Zhang Y, et al. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration. (2015) Science. 348(6240):aaa2340.