Product Information
| Purity: |
Affinity purification |
| Storage: |
Store at -20 or -80°C. Avoid freeze/thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3 |
Catalog No: A70037
HDAC4 Polyclonal Antibody
Application:
WB (1:500-1:2000)
IHC (1:50-1:200)
Cross-Reactivity: H, M, R
Caculated MW: 119 kDa
Species: Rabbit
Isotype: IgG
Purity: Affinity purification
Concentration: 1mg/mL
Storage:
Store at -20 or -80°C. Avoid freeze/thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Immunogen Information
Immunogen:
A synthetic peptide of human HDAC4
Gene ID: 9759
Swiss Prot: P56524
Synonyms:
HDAC; HA6116; HD4; HDAC-A; HDACA; KIAA0288
Background:
Histone deacetylase 4 (HDAC4) is a histone deacetylase that represses transcription when tethered to a promoter. It has been shown to interact with MEF2C, Zinc finger, CBX5, Nuclear receptorco-repressor1 and HDAC3 (1,2,3,4,5). In neurological findings, HDAC4 has been shown to shuttle between the nucleus and cytoplasm, controlling a transcriptional program essential for synaptic plasticity and memory. The nuclear import of HDAC4 represses genes encoding constituents of central synapses, thereby affecting synaptic architecture and strength (6).
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Reference:
1. Wang, A H et al. HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressors. (1999) Mol.Cell Biol (UNITED STATES) 19(11):7816–27.
2. Anne C et al. HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF". (2004) Oncogene (England) 23(54):8777–84.
3. Olson E N et al. Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation. (2002) Mol.Cell Biol. (United States) 22(20):7302–12.
4. Wolfgang F et al. Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR". (2002) Mol.Cell (United States) 9(1):45–57.
5. Fischle, W et al. Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo. (2001) J.Biol.Chem. (United States) 276(38):35826-35
6. Sando, R et al. HDAC4 Governs a Transcriptional Program Essential for Synaptic Plasticity and Memory. (2012) Cell 151(4):821-834.
