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StemRegenin1(SR1)---HSCExpansionMolecule

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StemRegenin1(SR1)---HSCExpansionMolecule

品牌：Xcessbio

货号：M60001-2s

规格：2 mg solid

货期：

应用：

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StemRegenin1(SR1)---HSCExpansionMolecule

商品详情参考文献相关资料

Product Information

Molecular Weight:	429.54
Formula:	C₂₄H₂₃N₅OS
Purity:	≥98%
CAS#:	1227633-49-9
Solubility:	DMSO up to 100 mM
Chemical Name:	4-(2-((2-(benzo[b]thiophen-3-yl)-9-isopropyl-9H-purin-6-yl)amino)ethyl)phenol
Storage:	Powder: 4^oC 1 year. DMSO: 4^oC 3 month; -20^oC 1 year.

Biological Activity:

StemRegenin1 (SR1) is a selective, cell-permeable antagonist of aryl hydrocarbon receptor.. It can promote robust expansion and self-renewal of human CD34+ peripheral blood and cord blood hematopoietic stem cells (HSCs, EC₅₀ ~120 nM). SR1 expanded CD34+ cells from bone marrow of humans, monkeys and dogs, but not mice. Culture of HSCs with 1 µM SR1 for 21 days led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice. Currently Novartis is conducting clinical trials, “LFU835-expanded Umbilical Cord Blood Hematopoietic Stem Cells in Patients With Hematological Malignancies”, related to this research.

How to Use:

In vitro: SR1 was used at 1 µM final concentration (DMSO 0.01%) in the ex vivo cell culture for 7-21 days. SR1 may be refreshed every 2-3 days during the culture.
In vivo: n/a

Reference:

1. Anthony E. Boitano et al. Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells. (2010) Science 329(5997):1345-8
2. Csaszar E, et al. Rapid expansion of human hematopoietic stem cells by automated control of inhibitory feedback signaling.(2012) Cell Stem Cell.10(2):218-29.

Products are for research use only. Not for human use.

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