人黑色素细胞是神经嵴衍生细胞，位于人的某些器官，如皮肤、眼睛、内耳和软脑膜。黑色素细胞不能向这些器官的移动，可以解释先天性皮肤白斑(斑驳病)跟虹膜异色(不同颜色并置)之间的关系以及Waardenburg综合征的先天性耳聋。皮肤黑色素细胞合成并转运黑色素到周围的角质细胞，使皮肤有色素沉积以保护皮肤对抗阳光辐射。随着新的细胞培养技术和改良的培养方法，在成功培养这类细胞在纯种群时，发现了新型的黑色素细胞基因——msgl，它能编码一种与色素沉着相关的核蛋白。
人表皮黑色素细胞(深色素)提取于人表皮组织，一代冻存。每管含有细胞数>5x10^5cells/ml，此细胞通过Fibronectin和NGF-receptor(p75)免疫荧光染色验证，经测试不含有HIV-1、HBV、HCV、支原体、细菌、酵母和真菌。细胞可以达到15倍增。
推荐培养基：黑色素细胞培养基 (MelM, Cat. #2201)
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货号
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2230
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产地
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美国
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缩写
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HEM-a
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规格
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5 x 10^5 /1ml
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用途
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科研
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储存
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液氮
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运输
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干冰
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2.) Looi CY, Moharram B, Paydar M, Wong YL, Leong KH, Mohamad K, Arya A, Wong WF, Mustafa MR. (2013) "Induction of apoptosis in melanoma A375 cells by a chloroform fraction of Centratherum anthelminticum (L.) seeds involves NF-kappaB, p53 and Bcl-2-controlled mitochondrial signaling pathways." BMC Complement Altern Med. 13: 166.
3.) Rotte A, Bhandaru M, Cheng Y, Sjoestroem C, Martinka M, and Li G. (2013) "Decreased Expression of Nuclear p300 Is Associated with Disease Progression and Worse Prognosis of Melanoma Patients." PLoS One. 8: e75405.
Question:
I purchased a HEM-a cell in February 2014 from ScienCell. Can you supply DNA (STR) profiling of this primary cell?
Thanks.
Answers:
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Posted by Manoj Sharma on Thursday, January 7, 2016
Hello,
We do not have STR profiling. thanks for your interest
SCIENCELL
