小胶质细胞是**神经系统中的胶质细胞类型之一，是神经胶质细胞网络的重要组成部分。小胶质细胞出现在大脑由发育早期向成熟阶段转化的过程中，被认为是大脑免疫监视的主要细胞。小胶质细胞也表达?II类主要组织相容性复合体（MHC?II），向CD4阳性T细胞呈递抗原，并能进行Fc段介导的胞吞作用，并且与造血细胞和组织巨噬细胞分享多种抗原。在大脑发育或**神经系统受伤发生程序性细胞死亡后，小胶质细胞能被激活。做为大脑的巨噬细胞清除组织碎片，受损细胞或微生物。另外，有大量的证据表明，小胶质细胞参与多种的生理和病理过程，它们通过与神经元和其它胶质细胞共同作用，产生诸如生长因子、细胞因子等活性物质来完成以上功能。
ScienCell实验室的HM提取自大脑皮层，原代冻存，冰冻运输。每管细胞密度*过1×106/ml。细胞经OX-42（CD11b/c）和F4/80免疫荧光鉴定。本细胞经检测不含HIV-1,?HBV,?HCV,?支原体,?细菌,?酵母菌和真菌。如采用ScienCell?实验室特制的培养基，可保证此细胞生长良好。HM不推荐增值培养。
推荐培养基：小胶质细胞培养基(MM, Cat. #1901)
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货号
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1900
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产地
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美国
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缩写
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HM
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规格
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5 x 10^5 /1ml
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用途
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科研
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储存
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液氮
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运输
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干冰
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4.) Campbell GR, Watkins JD, Singh KK, Loret EP, Spector SA. (2007) "Human Immunodeficiency Virus Type 1 Subtype C Tat Fails To Induce Intracellular Calcium Flux and Induces Reduced Tumor Necrosis Factor Production from Monocytes." J Virol. 81: 5919-28.
5.) Sui Z, Sniderhan LF, Schifitto G, Phipps RP, Gelbard HA, Dewhurst S, Maggirwar SB. (2007) "Functional Synergy between CD40 Ligand and HIV-1 Tat Contributes to Inflammation: Implications in HIV Type 1 Dementia." J Immunol. 178: 3226-36.
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1、Question:
Dear whom it may concern, I’m wondering whether your microglia express chemokine receptors particularly, CD36, TLR3, TLR4, TLR7. Any finding by you or your customers are valuable for me to use your cells as the model. Thanks, H.Cho
Answers:
We do not test for the receptors listed. Thank you for your interest in ScienCell products
2、Question:
Hello, Do these human microglia immortalized cells express CD80/86 as normal microglia do when stimulated? Also, are there any publications that utilized this cell line for flow cytometryic analysis? Thanks
Answers:
Human microglia provided by ScienCell are primary cells, not immortalized cell lines. Thank you for your interest
