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Anti-FANCA Antibody

品牌：Antibodies

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规格：50µl

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Anti-FANCA Antibody

商品详情参考文献相关资料

Name:	Anti-FANCA Antibody See all FANCA primary antibodies
Description:	Rabbit polyclonal antibody to FANCA.
Applications:	WB, IHC
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity:	Human
Immunogen:	Recombinant protein of human FANCA.
Protein Length:	1455
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Function:	DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.
Involvement in Disease:	Fanconi anemia, complementation group A: A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.
Post-Translational Modification:	Phosphorylation is required for the formation of the nuclear complex. Not phosphorylated in cells derived from groups A, B, C, E, F, G, and H.
Cellular locations:	Nucleus. Cytoplasm. The major form is nuclear. The minor form is cytoplasmic.
Database Links:	Entrez Gene: 2175?Human Omim: 607139?Human SwissProt: O15360?Human Unigene: 290154?Human
Synonyms:	FA Antibody FA 1 Antibody FA H Antibody FA1 Antibody FAA Antibody FACA Antibody FAH Antibody FANCA Antibody FANCA_HUMAN Antibody FANCH Antibody Fanconi anemia complementation group A Antibody Fanconi anemia complementation group H Antibody Fanconi anemia group A protein Antibody Fanconi anemia type 1 Antibody MGC75158 Antibody Protein FACA Antibody
Information:	Target information shown above is from the UniProt Consortium.