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Anti-ESX1 Antibody

品牌：Antibodies

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规格：100µl

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Anti-ESX1 Antibody

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Name:	Anti-ESX1 Antibody See all ESX1 primary antibodies
Description:	Rabbit polyclonal antibody to ESX1
Applications:	E, WB, IHC
Reactivity:	Human
Immunogen:	Raised against a 19 amino acid peptide near the center of human ESX1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Affinity chromatography purified via peptide column
Formulation:	Supplied in PBS containing 0.02% sodium azide.
Storage:	Can be stored at -20?C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Function:	May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover.
Tissue Specificity:	Expressed in placenta and testis. Expressed in testicular germ cell tumors.
Post-Translational Modification:	Undergoes proteolytic cleavage; produces a 45 kDa N-terminal homeodomain-containing fragment (ESXR1-N) and a 20 kDa C-terminal fragment (ESXR1-C).
Cellular locations:	Cytoplasm. Nucleus. ESXR1-N localizes specifically to the nucleus while ESXR1-C localizes specifically to the cytoplasm.
Database Links:	Entrez Gene: 80712?Human Omim: 300154?Human SwissProt: Q8N693?Human Unigene: 223782?Human
Synonyms:	Epx Antibody ESX1 Antibody ESX1L Antibody ESX1_HUMAN Antibody ESXR1 Antibody Etx Antibody Extraembryonic Antibody Extraembryonic spermatogenesis homeobox 1 Antibody homeobox 1 Antibody Homeobox protein ESX1-C Antibody spermatogenesis Antibody Spx1 Antibody
Information:	Target information shown above is from the UniProt Consortium.