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Anti-DUT Antibody

品牌：Antibodies

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规格：50µl

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Anti-DUT Antibody

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Name:	Anti-DUT Antibody See all DUT primary antibodies
Description:	Rabbit polyclonal antibody to DUT
Specificity:	DUT pAb detects endogenous levels of DUT protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant full length Human DUT.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 18, 26 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.

Function:	This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
Tissue Specificity:	Found in a variety of tissues. Isoform 3 expression is constitutive, while isoform 2 expression correlates with the onset of DNA replication (at protein level). Isoform 2 degradation coincides with the cessation of nuclear DNA replication (at protein level).
Sequence Similarities:	Belongs to the dUTPase family.
Post-Translational Modification:	Nuclear isoform 2 is phosphorylated in vivo on Ser-11, a reaction that can be catalyzed in vitro by CDC2. Phosphorylation in mature T-cells occurs in a cell cycle-dependent manner. Isoform 3 is not phosphorylated.
Cellular locations:	Nucleus.
Database Links:	Entrez Gene: 1854?Human Entrez Gene: 110074?Mouse Entrez Gene: 497778?Rat Omim: 601266?Human SwissProt: P33316?Human SwissProt: P70583?Rat Unigene: 527980?Human
Synonyms:	Deoxyuridine 5' triphosphate nucleotidohydrolase, nuclear isoform Antibody Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial Antibody Deoxyuridine triphosphatase Antibody DUT Antibody dUTP nucleotidohydrolase Antibody dUTP pyrophosphatase Antibody dUTPase Antibody DUT_HUMAN Antibody FLJ20622 Antibody
Information:	Target information shown above is from the UniProt Consortium.