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Anti-DACH2 Antibody

品牌：Antibodies

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规格：100µl

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Anti-DACH2 Antibody

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Name:	Anti-DACH2 Antibody See all DACH2 primary antibodies
Description:	Rabbit polyclonal antibody to DACH2
Specificity:	The antibody detects endogenous levels of total DACH2 protein.
Applications:	IHC
Reactivity:	Human
Immunogen:	Fusion protein corresponding to residues near the C terminal of human dachshund homolog 2 (Drosophila)
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1.9mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Function:	Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression (By similarity). Probably binds to DNA via its DACHbox-N domain.
Sequence Similarities:	Belongs to the DACH/dachshund family.
Cellular locations:	Nucleus.
Database Links:	Entrez Gene: 117154?Human Omim: 300608?Human SwissProt: Q96NX9?Human Unigene: 86603?Human
Synonyms:	DACH 2 Antibody DACH2 Antibody DACH2_HUMAN Antibody Dachshund 2 Antibody Dachshund homolog 2 Antibody Dachshund homolog 2 (Drosophila) Antibody Dachshund2 Antibody FLJ31391 Antibody HGNC:16814 Antibody MGC138545 Antibody
Information:	Target information shown above is from the UniProt Consortium.