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Anti-CDK4 (N-term) Antibody

品牌：Antibodies

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规格：50µl

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Anti-CDK4 (N-term) Antibody

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Overview

Name:	Anti-CDK4 (N-term) Antibody See all CDK4 primary antibodies
Description:	Mouse monoclonal antibody to CDK4 (N-term)
Applications:	WB, ICC
Dilutions:	Western blotting: 1:1000
Reactivity:	Human, Rabbit, Canine, Rat, Mouse
Immunogen:	Recombinant fragment, corresponding to amino acids 2-151aa of human CDK4(N-terminus).
Host:	Mouse
Clonality:	Monoclonal
Isotype:	IgG1
Conjugate:	Unconjugated
Purification:	Purified by antigen-affinity chromatography.
Predicted MW:	34kd
Formulation:	Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
Storage:	store at -20˚C

Target

Function:	Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocations and activity of the cyclin D-CDK4 complex.
Involvement in Disease:	Melanoma, cutaneous malignant 3: A malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but also may involve other sites.
Sequence Similarities:	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Post-Translational Modification:	Phosphorylation at Thr-172 is required for enzymatic activity. Phosphorylated, in vitro, at this site by CCNH-CDK7, but, in vivo, appears to be phosphorylated by a proline-directed kinase. In the cyclin D-CDK4-CDKN1B complex, this phosphorylation and consequent CDK4 enzyme activity, is dependent on the tyrosine phosphorylation state of CDKN1B. Thus, in proliferating cells, CDK4 within the complex is phosphorylated on Thr-172 in the T-loop. In resting cells, phosphorylation on Thr-172 is prevented by the non-tyrosine-phosphorylated form of CDKN1B.
Cellular locations:	Cytoplasm. Nucleus. Membrane. Cytoplasmic when non-complexed. Forms a cyclin D-CDK4 complex in the cytoplasm as cells progress through G(1) phase. The complex accumulates on the nuclear membrane and enters the nucleus on transition from G(1) to S phase. Also present in nucleoli and heterochromatin lumps. Colocalizes with RB1 after release into the nucleus.
Database Links:	Entrez Gene: 1019 Human Entrez Gene: 12567 Mouse Entrez Gene: 94201 Rat Omim: 123829 Human SwissProt: P11802 Human SwissProt: P30285 Mouse SwissProt: P35426 Rat Unigene: 95577 Human Unigene: 6839 Mouse Unigene: 6115 Rat
Synonyms:	Cdk 4 Antibody Cdk4 Antibody CDK4 protein Antibody CDK4_HUMAN Antibody Cell division kinase 4 Antibody Cell division protein kinase 4 Antibody CMM 3 Antibody CMM3 Antibody Crk3 Antibody Cyclin dependent kinase 4 Antibody Cyclin-dependent kinase 4 Antibody Melanoma cutaneous malignant 3 Antibody MGC14458 Antibody p34 cdk4 Antibody PSK J3 Antibody PSK-J3 Antibody
Information:	Target information shown above is from the UniProt Consortium.