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Anti-CCR4 Antibody

品牌：Antibodies

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规格：100µl

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应用：

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Anti-CCR4 Antibody

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Overview

Name:	Anti-CCR4 Antibody See all CCR4 primary antibodies
Description:	Rabbit polyclonal antibody to CCR4
Specificity:	The antibody detects endogenous levels of total CCR4 protein.
Applications:	IHC
Reactivity:	Human
Immunogen:	Synthetic peptide of human CCR4
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification
Concentration:	0.7mg / ml
Formulation:	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage:	Store at -20?C

Target

Function:	High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
Tissue Specificity:	Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells.
Sequence Similarities:	Belongs to the G-protein coupled receptor 1 family.
Post-Translational Modification:	In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.
Cellular locations:	Cell membrane.
Database Links:	Entrez Gene: 1233?Human GenBank: NP_005499.1?Human Omim: 604836?Human SwissProt: P51679?Human Unigene: 184926?Human
Synonyms:	C C chemokine receptor type 4 Antibody C C CKR 4 Antibody C-C chemokine receptor type 4 Antibody C-C CKR-4 Antibody CC CKR 4 Antibody CC-CKR-4 Antibody CCR 4 Antibody CCR-4 Antibody CCR4 Antibody CCR4_HUMAN Antibody CD194 Antibody Chemokine (CC motif) receptor 4 Antibody chemokine C C motif receptor 4 Antibody ChemR13 Antibody CKR4 Antibody CMKBR 4 Antibody CMKBR4 Antibody HGCN 14099 Antibody K5 5 Antibody K5-5 Antibody MGC88293 Antibody
Information:	Target information shown above is from the UniProt Consortium.