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Anti-CCND3 Antibody

品牌：Antibodies

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规格：100µl

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Anti-CCND3 Antibody

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Name:	Anti-CCND3 Antibody See all CCND3 primary antibodies
Description:	Rabbit polyclonal antibody to CCND3
Specificity:	The antibody detects endogenous levels of total CCND3 protein.
Applications:	IHC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to residues near the C terminal of human cyclin D3
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	2.8mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Function:	Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocations and activity of the cyclin D-CDK4 complex.
Sequence Similarities:	Belongs to the cyclin family. Cyclin D subfamily.
Post-Translational Modification:	Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.
Cellular locations:	Nucleus. Cytoplasm. Membrane. Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members.