Anti-Caveolin-1 (phospho-Y14) Antibody |产品详情|进口橙子视频旧款采购网

您好，欢迎来到橙子视频app安卓下载生物网站！请登录注册

我的订单 | 联系橙子视频app安卓下载 | 在线客服QQ：3012681483 | 客服电话：400-968-7988 | 工作时间：08:30-17:30

主营产品： ELISA91橙子视频、抗体、补体血清、兔补体、干扰素、小鼠测温仪、进口橙子视频旧款、Quidel代理、Swant代理、PBL Assay Science代理

网站首页产品中心代理品牌新闻资讯资源中心关于橙子视频app安卓下载

所在位置：首页 > 产品中心 > Antibodies > Antibodies产品

订购信息

上海橙子视频app安卓下载生物科技公司

Tel:400-968-7988 021-33779008

Anti-Caveolin-1 (phospho-Y14) Antibody

品牌：Antibodies

货号：

规格：50µl

货期：

应用：

咨询客服

立即购买加入购物车

Anti-Caveolin-1 (phospho-Y14) Antibody

商品详情参考文献相关资料

Overview

Name:	Anti-Caveolin-1 (phospho-Y14) Antibody See all Caveolin-1 primary antibodies
Description:	Rabbit polyclonal antibody to Caveolin-1 (phospho-Y14)
Specificity:	p-Caveolin-1 (Y14) pAb detects endogenous levels of Caveolin-1 protein only when phosphorylated at Tyr14.
Applications:	WB
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic phosphopeptide derived from human Caveolin-1 around the phosphorylation site of Tyrosine 14.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 20, 25 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292).
Tissue Specificity:	Expressed in muscle and lung, less so in liver, brain and kidney.
Involvement in Disease:	Congenital generalized lipodsystrophy 3: An autosomal recessive disorder characterized by a near complete absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes. Pulmonary hypertension, primary, 3: A rare disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial pulmonary hypertension is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs. Partial lipodsystrophy, congenital cataracts, and neurodegeneration syndrome: A form of familial partial lipodsystrophy associated with congenital cataracts and neurodegeneration leading to cerebellar and spinal cord dysfunction.
Sequence Similarities:	Belongs to the caveolin family.
Post-Translational Modification:	The initiator methionine for isoform 2 is removed during or just after translation. The new N-terminal amino acid is then N-acetylated.
Cellular locations:	Golgi apparatus membrane. Cell membrane. Membrane > Caveola. Membrane raft. Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.
Database Links:	Entrez Gene: 857 Human Entrez Gene: 12389 Mouse Entrez Gene: 25404 Rat Omim: 601047 Human SwissProt: Q03135 Human SwissProt: P49817 Mouse SwissProt: P41350 Rat Unigene: 74034 Human Unigene: 28278 Mouse Unigene: 470537 Mouse Unigene: 22518 Rat
Synonyms:	BSCL3 Antibody CAV Antibody CAV1 Antibody CAV1_HUMAN Antibody caveolae protein, 22 kD Antibody caveolin 1 alpha isoform Antibody caveolin 1 beta isoform Antibody Caveolin 1 caveolae protein 22kDa Antibody Caveolin-1 Antibody Caveolin1 Antibody cell growth-inhibiting protein 32 Antibody CGL3 Antibody LCCNS Antibody MSTP085 Antibody OTTHUMP00000025031 Antibody PPH3 Antibody VIP 21 Antibody VIP21 Antibody
Information:	Target information shown above is from the UniProt Consortium.