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Anti-Bcl-6 Antibody

品牌：Antibodies

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规格：50µl

货期：

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Anti-Bcl-6 Antibody

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Overview

Name:	Anti-Bcl-6 Antibody See all Bcl-6 primary antibodies
Description:	Rabbit polyclonal antibody to Bcl-6
Specificity:	Bcl-6 Polyclonal Antibody detects endogenous levels of Bcl-6 protein.
Applications:	WB, IHC, ELISA
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthesized peptide derived from human Bcl-6 around the non-phosphorylation site of S333.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1mg / ml
Formulation:	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage:	Store at -20?C / 1 year

Target

Function:	Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4(+) T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.
Tissue Specificity:	Expressed in germinal center T- and B-cells and in primary immature dendritic cells.
Post-Translational Modification:	Phosphorylated by MAPK1 in response to antigen receptor activation at Ser-333 and Ser-343. Phosphorylated by ATM in response to genotoxic stress. Phosphorylation induces its degradation by ubiquitin/proteasome pathway.
Cellular locations:	Nucleus.
Database Links:	Entrez Gene: 604?Human Omim: 109565?Human SwissProt: P41182?Human Unigene: 478588?Human
Synonyms:	B Cell Lymphoma 6 Protein Antibody B-cell CLL/lymphoma 6 Antibody B-cell lymphoma 5 protein Antibody B-cell lymphoma 6 protein transcript Antibody bcl-6 Antibody BCL5 Antibody BCL6A Antibody cys-his2 zinc finger transcription factor Antibody LAZ3 Antibody lymphoma-associated zinc finger gene on chromosome 3 Antibody Protein LAZ-3 Antibody ZBTB27 Antibody Zinc finger and BTB domain-containing protein 27 Antibody Zinc Finger Protein 51 Antibody zinc finger transcription factor BCL6S Antibody ZNF51 Antibody
Information:	Target information shown above is from the UniProt Consortium.