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Anti-Podocin Antibody

品牌：Antibodies

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规格：50µl

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Anti-Podocin Antibody

商品详情参考文献相关资料

Name:	Anti-Podocin Antibody See all Podocin primary antibodies
Description:	Rabbit polyclonal antibody to Podocin
Specificity:	Podocin pAb detects endogenous levels of Podocin protein.
Applications:	WB
Reactivity:	Human, Mouse, Rat
Immunogen:	A synthetic peptide corresponding to residues in Human Podocin.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 42 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.

Function:	Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton.
Tissue Specificity:	Almost exclusively expressed in the podocytes of fetal and mature kidney glomeruli.
Involvement in Disease:	Nephrotic syndrome 2: A form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. The disorder is resistant to steroid treatment and progresses to end-stage renal failure in the first or second decades. Some patients show later onset of the disorder.
Sequence Similarities:	Belongs to the band 7/mec-2 family.
Post-Translational Modification:	Isoform 2 is glycosylated.
Cellular locations:	Cell membrane.
Database Links:	Entrez Gene: 7827 Human Entrez Gene: 170484 Mouse Entrez Gene: 170672 Rat Omim: 604766 Human SwissProt: Q9NP85 Human SwissProt: Q91X05 Mouse SwissProt: Q8K4G9 Rat Unigene: 412710 Human Unigene: 289099 Mouse Unigene: 86433 Rat
Synonyms:	nephrosis 2, idiopathic, steroid resistant Antibody Nephrosis 2, idiopathic, steroid resistant (podocin) Antibody NPHS2 Antibody NPHS2 gene Antibody PDCN Antibody Podocin Antibody PODO_HUMAN Antibody SRN1 Antibody
Information:	Target information shown above is from the UniProt Consortium.