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Anti-SCO1 Antibody

品牌：Antibodies

货号：

规格：50µl

货期：

应用：

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Anti-SCO1 Antibody

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Overview

Name:	Anti-SCO1 Antibody See all SCO1 primary antibodies
Description:	Rabbit polyclonal antibody to SCO1.
Applications:	WB, IHC
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human SCO1.
Protein Length:	301
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Thought to play a role in cellular copper homeostasis, mitochondrial redox signaling or insertion of copper into the active site of COX.
Tissue Specificity:	Predominantly expressed in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain.
Involvement in Disease:	Mitochondrial complex IV deficiency: A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, exercise intolerance, developmental delay, delayed motor development and mental retardation. Some affected individuals manifest a fatal hypertrophic cardiomyopathy resulting in neonatal death. A subset of patients manifest Leigh syndrome.
Sequence Similarities:	Belongs to the SCO1/2 family.
Cellular locations:	Mitochondrion.
Database Links:	Entrez Gene: 6341?Human Entrez Gene: 52892?Mouse Entrez Gene: 497930?Rat Omim: 603644?Human SwissProt: O75880?Human SwissProt: Q5SUC9?Mouse Unigene: 14511?Human Unigene: 129731?Mouse Unigene: 473182?Mouse Unigene: 203819?Rat
Synonyms:	Cytochrome oxidase deficient homolog Antibody Cytochrome oxidase deficient homolog 1 Antibody Protein SCO1 homolog mitochondrial Antibody Protein SCO1 homolog, mitochondrial Antibody SCO (cytochrome oxidase deficient yeast) homolog 1 Antibody SCO cytochrome oxidase deficient homolog 1 Antibody SCO cytochrome oxidase deficient homolog 1 (yeast) Antibody SCO1 Antibody SCO1_HUMAN Antibody SCOD1 Antibody
Information:	Target information shown above is from the UniProt Consortium.