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Anti-WT1-AS Antibody

品牌：Antibodies

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规格：50µl

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Anti-WT1-AS Antibody

商品详情参考文献相关资料

Overview

Name:	Anti-WT1-AS Antibody See all WT1-AS primary antibodies
Description:	Rabbit polyclonal antibody to WT1-AS
Specificity:	WT1-AS pAb detects endogenous levels of WT1-AS protein.
Applications:	WB
Reactivity:	Human, Mouse, Rat
Immunogen:	A synthetic peptide corresponding to residues in Human WT1-AS.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 15 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Introduction:

Wilms’ tumor is a neoplasm of the kidneys that usually occurs in children and is characterized by the presence of abortive tubules and glomeruli surrounded by a spindled cell stroma. The 11p13 Wilms’ tumor locus consists of two coordinately regulated transcripts, WT1 and WIT-1, which are mutated in Wilms’ tumors. Wilms’ tumor upstream neighbor 1 (WIT-1) is encoded by an intron-less gene upstream of the Wilms’ tumor 1 (WT1) gene, which is is important for nephrogenesis and gonadal growth. The WT1 gene is bi-directionally transcribed from the same promoter region as WIT-1, which may function as an antisense regulator of WT1. WIT-1 and WT1 have the same temporal and cell-restricted expression pattern, although the expression of WIT-1 is less abundant. Methylation of the WIT-1 gene is implicated in hematologic malignancy of chemoresistant acute myeloid leukemia. Single nucleotide polymorphisms (SNPs) in the WIT-1 gene are significantly associated with focal segmental glomerulosclerosis.

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