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Anti-HDAC3 Antibody

品牌：Antibodies

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规格：100µg

货期：

应用：

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Anti-HDAC3 Antibody

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Overview

Name:	Anti-HDAC3 Antibody See all HDAC3 primary antibodies
Description:	Goat polyclonal antibody to HDAC3.
Applications:	ELISA, WB
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human HDAC3 (internal region).
Sequence:	C-NHAPSVQIHDVPAD
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 µg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI(3)K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803).
Tissue Specificity:	Widely expressed.
Sequence Similarities:	Belongs to the histone deacetylase family. HD type 1 subfamily.
Post-Translational Modification:	Sumoylated in vitro.
Cellular locations:	Nucleus. Cytoplasm. Cytoplasm > Cytosol. Colocalizes with XBP1 and AKT1 in the cytoplasm (PubMed:25190803). Predominantly expressed in the nucleus in the presence of CCAR2.
Database Links:	Entrez Gene: 8841 Human Omim: 605166 Human SwissProt: O15379 Human Unigene: 519632 Human
Synonyms:	HD3 Antibody HDAC 3 Antibody HDAC3 Antibody HDAC3_HUMAN Antibody Histone deacetylase 3 Antibody RPD3 Antibody RPD3 2 Antibody RPD3-2 Antibody SMAP45 Antibody
Information:	Target information shown above is from the UniProt Consortium.