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Anti-RASGRP4 Antibody

品牌：Antibodies

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规格：100µl

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Anti-RASGRP4 Antibody

商品详情参考文献相关资料

Name:	Anti-RASGRP4 Antibody See all RASGRP4 primary antibodies
Description:	Rabbit polyclonal antibody to RASGRP4
Applications:	WB, IHC, IF
Reactivity:	Human
Immunogen:	Synthetic peptide contain a sequence corresponding to a region within amino acids 108 and 170 of Human RASGRP4
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Purified by antigen-affinity chromatography.
Formulation:	Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.
Storage:	Store at -20?C for long term preservation (recommended). Store at 4?C for short term use.

Function:	Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation.
Tissue Specificity:	Expressed by mast cells and their progenitors (at protein level). Specifically expressed in mononuclear leukocytes. Highly expressed in myeloid cells compared to lymphoid cells. Also detected in heart, skeletal muscle, spleen, liver, placenta and lung. Not detected in brain. Isoform 1 is the major isoform in normal individuals. Isoform 2 is more significantly expressed in a patient with asthma. Isoform 3 is more significantly expressed in a patient with asthma and a mastocytosis patient.
Sequence Similarities:	Belongs to the RASGRP family.
Cellular locations:	Cytoplasm. Cell membrane. Recruited to membranes upon activation by DAG.
Database Links:	Entrez Gene: 115727?Human Omim: 607320?Human SwissProt: Q8TDF6?Human Unigene: 130434?Human
Synonyms:	GRP4_HUMAN Antibody Guanyl nucleotide releasing protein 4 Antibody RAS guanyl releasing protein 4 Antibody RAS guanyl-releasing protein 4 Antibody RASGRP 4 Antibody RASGRP4 Antibody
Information:	Target information shown above is from the UniProt Consortium.