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Anti-PRDM14 Antibody

品牌：Antibodies

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规格：50µl

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Anti-PRDM14 Antibody

商品详情参考文献相关资料

Name:	Anti-PRDM14 Antibody See all PRDM14 primary antibodies
Description:	Rabbit polyclonal antibody to PRDM14.
Applications:	WB, IHC, IF, IP, ChIP
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200, IP: 1:20 - 1:100, ChIP: 1:20 - 1:100.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human PRDM14.
Protein Length:	571
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Function:	Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'.
Tissue Specificity:	Expressed in embryonic stem cells. Tends to be overexpressed in breast cancer (at protein level).
Sequence Similarities:	Belongs to the class V-like SAM-binding methyltransferase superfamily.
Cellular locations:	Nucleus.
Database Links:	Entrez Gene: 63978?Human Entrez Gene: 383491?Mouse Entrez Gene: 297769?Rat Omim: 611781?Human SwissProt: Q9GZV8?Human SwissProt: E9Q3T6?Mouse Unigene: 287532?Human Unigene: 309380?Mouse
Synonyms:	MGC59730 Antibody PFM 11 Antibody PFM11 Antibody PR domain containing 14 Antibody PR domain zinc finger protein 14 Antibody PR domain-containing protein 14 Antibody PRD14_HUMAN Antibody PRDM 14 Antibody PRDM14 Antibody
Information:	Target information shown above is from the UniProt Consortium.