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Anti-p63 Protein Antibody

品牌：Antibodies

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规格：5ml

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Anti-p63 Protein Antibody

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Overview

Name:	Anti-p63 Protein Antibody See all p63 primary antibodies
Description:	Mouse monoclonal (4A4) antibody to p63 Protein.
Specificity:	p63 protein (nuclear), 6 Isotypes.
Applications:	IHC
Reactivity:	Human, Mouse, Rat?
Immunogen:	Recombinant human p63 protein (aa 1-205).
Host:	Mouse
Clonality:	Monoclonal
Clone:	4A4
Isotype:	IgG2a
Conjugate:	Unconjugated
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes:	p63 is known as an excellent marker of basal cells in squamous epithelia and transitional cell epithelia (localisation of the antigen in cell nuclei) . It is well suited for the detection of squamous cell carcinoma. In prostate tissue 80% of basal cells in benign tissue react positive, whereas p63 disappears in prostate carcinoma.

Target

Function:	Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Activates RIPK4 transcription (By similarity). Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter (By similarity).
Tissue Specificity:	Widely expressed, notably in thymus, prostate, placenta, and skeletal muscle, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast and prostate express high levels of DeltaN-type isoforms.
Sequence Similarities:	Belongs to the p53 family.
Post-Translational Modification:	May be sumoylated.
Cellular locations:	Nucleus.
Database Links:	Entrez Gene: 8626?Human Entrez Gene: 22061?Mouse Entrez Gene: 246334?Rat Omim: 603273?Human SwissProt: Q9H3D4?Human SwissProt: O88898?Mouse SwissProt: Q9JJP6?Rat Unigene: 137569?Human Unigene: 20894?Mouse Unigene: 42907?Rat
Synonyms:	AIS Antibody Amplified in squamous cell carcinoma Antibody B(p51A) Antibody B(p51B) Antibody Chronic ulcerative stomatitis protein Antibody CUSP Antibody DN p63 alpha 1 Antibody DNp63 Antibody EEC3 Antibody id:ibd3516 Antibody Keratinocyte transcription factor Antibody Keratinocyte transcription factor KET Antibody KET Antibody LMS Antibody MGC115972 Antibody MGC192897 Antibody NBP Antibody OFC8 Antibody OTTHUMP00000209732 Antibody OTTHUMP00000209733 Antibody OTTHUMP00000209734 Antibody OTTHUMP00000209735 Antibody OTTHUMP00000209737 Antibody OTTHUMP00000209738 Antibody OTTHUMP00000209739 Antibody OTTHUMP00000209740 Antibody OTTHUMP00000209741 Antibody OTTHUMP00000209742 Antibody OTTHUMP00000209743 Antibody OTTHUMP00000209744 Antibody p40 Antibody p51 Antibody P51/P63 Antibody p53-related protein p63 Antibody p53CP Antibody p63 Antibody P63_HUMAN Antibody p73H Antibody p73L Antibody RHS Antibody SHFM4 Antibody TAp63alpha Antibody TP53CP Antibody TP53L Antibody TP63 Antibody TP73L Antibody Transformation related protein 63 Antibody Transformation-related protein 63 Antibody Trp53rp1 Antibody Trp63 Antibody Tumor protein 63 Antibody Tumor protein p53-competing protein Antibody Tumor protein p53-like Antibody Tumor protein p63 Antibody Tumor protein p63 deltaN isoform delta Antibody Tumor protein p73 Antibody Tumor protein p73-like Antibody
Information:	Target information shown above is from the UniProt Consortium.