–  Hydrodynamic size: diameter is 25-30 nm

–  Fe content : > 5000 Fe atoms per particle

–  Recommended dose: 200 μmol/kg = 2.5 μL/g

Example: for a 30g body weight mouse injection, volume is 75 μL

 

–  Relaxivities ( s-1.mM-1, 37°C; 4% Human Albumin Serum, medium closed to plasma)

–  Qualitative techniques: Perl’s staining

–  In vitro quantification techniques: P904 is a Fe-based contrast agent. Thus, it is necessary to take into account the endoge- nous iron content for quantification in biological media by ICP- AES or ICP-MS. Another way for USPIO quantification is rela- xometry, which is poorly sensitive to endogenous iron content.