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产品描述
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A murine monoclonal antibody to an epitope in the C3d domain of C3.
This monoclonal antibody was raised against purified human C. It is specific for an antigen expressed on the C3d domain of C3 and therefore reactive to C3 and all C3d-containing fragments of C3.
Quidel's C3 (C3d) monoclonal antibody has been used in a variety of experimental techniques including EIA, Western Blot, and Immunohistochemistry.
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背景
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The human complement component C3 consists of two disulfide bonded subunits (Alpha 115 kD and Beta 75 kD). The concentration of C3 in serum is approximately 1.25 +/- 0.52 mg/mL. Under normal conditions, activation of either of the complement pathways leads to C3 conver- tases, which cleave C3 into two fragments C3a, an anaphylatoxin, and C3b. The C3b fragment has many biologic functions including promo- tion of phagocytosis and participation as a structural component of both the C3 and C5 convertase enzymes. These processes are under strin- gent control in vivo
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参考资料
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1、Stoltzner, S., Lemere, C. et al. Temporal accrual of complement proteins in Amyloid plaques in patients with Down syndrome with Alzheimer's Disease, Am J Path 156:489-499, 2000.
2、Gemmell, C. A flow cytometric immunoassay to quantify adsorption of complement activation products on artificial surfaces, J Biomed Mater Res 37, 474-480, 1997.
3、Rogers, J., Cooper, N., et al. Complement Activation by ß-amyloid in Alzheimer disease. PNAS 89:10016-10020, 1992.
4、Tamerius, J.D., Pangburn, M.K., et al. Selective inhibition of functional sites of cell bound C3b by hybridoma derived antibodies, J. Immunol 128:512, 1982.
5、Tamerius, J.D., Pangburn, M.K., et al. Detection of a neoAntigen on human iC3b and C3d by monoclonal Antibody, J. Immunol. 135:2015, 1985.
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